BIOQUAL Insights
Publications
Featured Publications
Respiratory Infections
SARS-Cov-2
- BCG immunization mitigates SARS-CoV-2 replication in macaques via monocyte efferocytosis and neutrophil recruitment in lungs
- Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
- Use of a Multiplex Immunoassay Platform to Investigate Multifaceted Antibody Responses in SARS-CoV-2 Vaccinees with and Without Prior Infection
- Suppression of miR-155 Attenuates Lung Cytokine Storm Induced by SARS-CoV-2 Infection
- Multi-Antigen Viral-Vectored Vaccine Protects Against SARS-CoV-2 and Variants in a Lethal hACE2 Transgenic Mouse Model
- Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters
- NELL1 variant protein (NV1) modulates hyper-inflammation, Th-1 mediated immune response, and the HIF-1α hypoxia pathway to promote healing in viral-induced lung injury
- Suppression of miR-155 Attenuates Lung Cytokine Storm Induced by SARS-CoV-2 Infection
- Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters
- Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates
- Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
- NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage
- AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults
- Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer
- Study of immunogenicity and efficacy against Omicron BA.5 of recombinant protein-based COVID-19 vaccine delivered by intramuscular and mucosal routes in nonhuman primates
- Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques
- SARS-CoV-2 mucosal vaccine protects against clinical disease with sex bias in efficacy
- A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo
- Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infection/li>
Influenza
HIV/AIDS/SHIV/SIV
- Neonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques
- Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs
- Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates
- Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques
- Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development
Mosquito-borne Viruses
Orthopox Viruses
- Mpox infection of stromal cells and macrophages of macaque with endometriosis
- Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques
- A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease
- Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus
Other
Publication Archive
Respiratory Infections
SARS-CoV-2
- SARS-CoV-2 infection protects against rechallenge in rhesus macaques
- Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
- NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge
- Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2
- Potently neutralizing and protective human antibodies against SARS-CoV-2
- The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection
- REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
- Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters
- SARS-CoV-2 infection augments species- and age-specific predispositions in cotton rats
- Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19
- Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
- Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
- Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice
- One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization
- Heterologous chimpanzee adenovirus vector immunizations for SARS-CoV-2 spike and nucleocapsid protect hamsters against COVID-19
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
- Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice
- The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients
- Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters
- Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments
- Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
- Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters
- Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters
- Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern
- A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge
- COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variants
- Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants
- Protection from COVID-19 disease in hamsters vaccinated with subunit SARS-CoV-2 S1 mucosal vaccines adjuvanted with different adjuvants
- Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters
- Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer
- SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Influenza
- Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates
- A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection
- Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens
- Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure
- Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates
- Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza
- Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
- Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies
- Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses
- Efficacy of anti-influenza immunoglobulin (FLU-IGIV) in ferrets and mice infected with 2009 pandemic influenza virus
- Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret
- Aerosolized adenovirus-vectored vaccine as an alternative vaccine delivery method
- A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge
- Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus
- Highly pathogenic avian influenza A virus (H5N1) can be transmitted in ferrets by transfusion
- Induction of broadly neutralizing H1N1 influenza antibodies by vaccination
- Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
- Quadrivalent influenza nanoparticle vaccines induce broad protection
- The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017
Tuberculosis
Herpesvirus
HIV/AIDS/SHIV/SIV
- Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens
- IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells
- Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques
- Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
- In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model
- Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine
- Rapid Loss of CD4 T Cells by Pyroptosis during Acute SIV Infection in Rhesus Macaques
- HIV Env conserved element DNA vaccine alters immunodominance in macaques
- A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
- Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail
- Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys
- Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge
- Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women
- Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens
- Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
Mosquito-borne Infections
- An Envelope-Modified Tetravalent Dengue Virus-Like-Particle Vaccine Has Implications for Flavivirus Vaccine Design
- A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection
- A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates
- Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies
- Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques
- Development of a potent Zika virus vaccine using self-amplifying messenger RNA
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus
- Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria